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Amyotrophic Lateral Sclerosos
Amyotrophic Lateral Sclerosis (ALS), recurrently known as Lou Gehrig’s is an incorrigible, progressive degenerative neurological disorder. The nerve cells of the brain and spinal cord that control voluntary muscle movement gradually decline for reasons unidentified. The muscles become emaciated, leading to paralysis and death of the individual in 2-5 years’ time. The only neurons affected are the lower motor nerve cells which control a catholic array of things like movement of limbs, swallowing and even breathing. Motor neurons run from brain to the spinal cord and from the spinal cord to the muscles all over the body. The gradual degeneration of the motor neurons eventually results in their demise. When motor neurons expire, the aptitude of the brain to begin and control muscle movement is lost. This also affects a person’s aptitude to speak, eat, move and breathe. In ALS, the motor neurons that provide voluntary movements and muscle control are affected. Research has revealed a wealth of new scientific understanding about the physiology of this disease. Stem cell treatment has emerged as an effective treatment option for ALS.

Symptoms


The beginning of ALS may be so blurred that the symptoms are frequently ignored. The earliest symptoms may include:
  • slurred and nasal speech
  • difficulty chewing or swallowing
  • muscle weakness affecting an arm or a leg
  • spasms, cramps, or stiffness of muscles

Contingent on the muscles in the body that are impaired first the initial symptoms of ALS surface. Symptoms initially affect one of the legs and patients experience difficulty in running or walking, or they experience they are stumbling or tripping more often. The signs of disease first appear on hands or arms and they experience trouble in pursuing simple tasks requiring manual agility such as writing, turning a key in a lock and other. Some patients notice speech problems.ALS affects the upper motor neurons, which are in the brain, and the lower motor neurons, which are in the spinal cord and brainstem. Upper motor neuron degeneration usually causes spasticity (tightness in a muscle), while lower motor neuron degeneration causes muscle weakness, muscle atrophy (shrinkage of muscles) and twitching. These can happen in combination in ALS, as upper and lower motor neurons are being lost simultaneously.Though it typically strikes people in their late mid age, ALS can affect individuals of any age. It is characterized by persistent weakness or spasticity in an arm or leg. The problem originated in the muscles controlling speech or swallowing. People encountering such problems cannot ignore the issue and must see a doctor.

Treatment


We use the matchless technology of Mesenchymal stem cells mined from Wharton’s jelly (WJ) for treating ALS.  WJ-MSCs offer economical and pain-free collection method that might be cryogenic ally stockpiled and are tremendously advantageous for tissue engineering purpose. The treatment will come about in four steps which consist of:

Qualification for the treatment: Our specialists will probe your past medical history and symptoms to gauge the severity of your condition. A series of examinations will be implemented to comprehend the phase of disease. There will be pre-treatment evaluations and pre-operative evaluations. According to the test outcomes, our specialists will recommend the patient for further course of the process.

Source Extraction: With supervision and approval from the doctor, the source of extraction will be decided. On the whole, WJ-MSCs are the most potent allogenic sources obtainable. Stem cells from a healthy individual (the donor) are transported to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the interiors of the patient and his or her sibling’s cheek is tested to ascertain the tissue type. A professional will scrutinize to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or alike, the transplant is more likely to be prosperous.

Laboratory Processing: The extracted samples will be sent to government approved cGMP lab for processing. The sample management will take place in an ultramodern facility in defiance with the ISO and GMP standards and using the newest technologies. The customer will receive a third party certificate from globally accredited lab for quality purpose.

Stem Cell Implantation: Once the stem cells are prepared to be implanted, the physician will pinpoint the most potent technique of infusion centered on the patient’s physical and mental well-being.

ALS Stem Cell Treatment Aftercare: in this phase, the patient will be asked to visit the doctor. The doctor might recommend some rehabilitation programmes such as communication and social interaction, physiological counseling and additional assessment.

Treatment Aftercare: The patients will be requested to visit the doctors for some examinations to evaluate the improvement.  Suggestive rehabilitation programs might include behavior and emotional development, communication and social interaction, self-regulation, cognitive and adaptive abilities.

FAQs


What Is ALS?
ALS is that the disease poignant the brain cells prevalently referred to as neurons linking brain with alternative components of the body. These neurons act as messengers to convey signals from brain to muscles to permit the voluntary movements of the body. Thanks to some external or internal factors, these cells expire or degenerate thus losing the power to convey signals to muscles. This causes the muscles to be feeble occasioning in palsy.

What causes ALS?
Although, ALS has been awfully current worldwide, scientists record measure still group action to grasp the exact cause and mechanism for ALS. There are to this point several studies to scrutinize totally different sides, which can be joined up with ALS. Though studies record measure relating the sickness for numerous genetic variations, there is however way to be assumed.

Is ALS joined to the setting?
Clinical studies to this point haven’t found conclusive environmental factors which will be linked with ALS except some generalized studies connecting it to the potential exposure of bound chemicals like lead or mercury.

Is ALS equally common in both the genders?
ALS, that has been brought about due to a few environmental factors, is decided to be barely lots of common in men than in girls. However it’s conjointly been in accordance lately that the distinction is reducing over the time. At a comparable time, familial ALS i.e. ALS related to the genetic versions is similarly not rare in every the genders.

Is ALS associated with age?
ALS is generally age related; maximum of the individuals resolve that they are suffering with ALS after they are between 55-75 years in age.

How long do folks with ALS live?
Maximum of the individuals with ALS have determined to be living for three to five years when the symptoms will ripen. Though, the precise lifetime of the individual with ALS isrelated with age.

Can ALS be ancestral?
It has been determined that approximately about 5-10% of the full ALS cases are ancestral ALS i.e. they are mainly caused owing to the shortcoming within the factor that is typically referred to as “SOD1”

What is an efferent neuron disease?
ALS falls beneath a bunch of conditions referred to as efferent neuron sickness. In ALS, muscles concerned within the voluntary movements of each higher and lower body are affected.  On a median, ALS usually accounts for the eighty fifth of efferent neuron diseases.

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