It is predictable that spinal muscular atrophy affects one in 7000 babies born and that around one in 50 folks are hereditary carriers of the ailment. SMA is an autosomal recessive genetic disorder which means that maximum circumstances of SMA can be credited to getting inferior genes from both parents. It is believed that if both parents are carriers of this genetic disorder to chance of the child developing this infection is 25%. Prospective parents can use genetic testing to see if they are carriers of this gene though PGD pre-implementation genetic diagnosis testing that is obtainable in maximum countries around the globe. There are 4 kinds and classifications of SMA disease
- SMA type I which is the most severe category is also acknowledged as Werdnig-Hoffman disease.
- SMA type II is less severe than type I asked patients usually infants do not exhibit symptoms of SMA during early emergent stage however over time they become feebler and weaker.
- SMA type III is less severe form and usually starts in initial adulthood and steadily gets worse as the patient’s age.
- SMA type IV is the least severe grouping of the disease where weakness and muscle wasting generally start in adulthood.
Owing to its hereditary nature, there is no everlasting cure for this disease. Neural stem cell transplants and gene therapy are at the moment the most effective treatment alternatives for control and remission of spinal-muscular atrophy.
Muscle weakness in the legs and shoulder muscles are the foremost indications of the disease. Weakness and muscle atrophy get significantly worse over time and can eventually lead to complete paralysis and death. Patients with SMA also have considerable difficulty with physical actions such as walking, crawling and eye coordination, neck and hand control and dysphagia (trouble swallowing). Patients with SMA also have threateningly higher risk for developing breathing complication sowing to the respiratory muscles in the lungs failing. Other symptoms take account of:
- Muscle atrophy
- Muscle feebleness
- Trouble Breathing
- Reedy muscle mass
- Trouble eating or swallowing
- Deficit of head and neck control
- Reflex facial jerking
- Atrophic muscle changes
- Muscle vibrating
- Sensory neuropathies
- Difficulty in sitting up or walking or crawling (infants )
- Reedy muscle mass
- Missing tendon reflexes
- Impotency,ED and/or decrease in sexual potency
Spinal Muscular Atrophy (SMA) patients treated with stem cells normally perceive improvements in the following regions:
- Motor Function
- Neuropathic pain
- Muscle tone and strength
- Fine and gross motor
- Decelerated progression
We use the matchless technology of Mesenchymal stem cells mined from Wharton’s jelly (WJ) for treating spinal cord injury. WJ-MSCs offer economical and pain-free collection technique that might be cryogenically stockpiled and are tremendously advantageous for tissue engineering purpose. The treatment will come about in four steps which consist of:
Qualification for the treatment: Our specialists will probe your past medical history and symptoms to gauge the severity of your condition. A series of examinations will be implemented to comprehend the phase of disease. There will be pre-treatment evaluations and pre-operative evaluations. According to the test outcomes, our specialists will recommend the patient for further course of the process.
Source Extraction: With supervision and approval from the doctor, the source of extraction will be decided. On the whole, WJ-MSCs are the most potent allogenic sources obtainable. Stem cells from a healthy individual (the donor) are transported to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the interiors of the patient and his or her sibling’s cheek is tested to ascertain the tissue type. A professional will scrutinize to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or alike, the transplant is more likely to be prosperous.
Laboratory Processing: The extracted samples will be sent to government approved cGMP lab for processing. The sample management will take place in an ultramodern facility in defiance with the ISO and GMP standards and using the newest technologies. The customer will receive a third party certificate from globally accredited lab for quality purpose.
Stem Cell Implantation: Once the stem cells are prepared to be implanted, the physician will pinpoint the most potent technique of infusion centered on the patient’s physical and mental well-being.
Spinal Cord Injury Stem Cell Treatment Aftercare: in this stage, the patient will be asked to visit the doctor. The doctor might recommend some rehabilitation programmes such as communication and social interaction, physiological counseling and further assessment.