What is Optic Nerve Hypoplasia?
Optic nerve hypoplasia (ONH) befalls from the underdevelopment of the optic nerve, the sole purpose of which is to carry neuronal transmission from the retina in the eye to the brain. Septo-optic dysplasia (SOD), also recognized as de Morsier syndrome, is a subtype of ONH and ascends from the underdevelopment of the optic nerve, pituitary gland dysfunction, and deficiency of the septum pellucid, which is a midline region of the brain. SOD ascends from shortcomings during the embryological development of babies, and studies show that ONH might be connected to some gene defects as well as embryo exposure to infections. Along with this, the deficiency of vision, which is a characteristic symptom of ONH, SOD also elicits other symptoms such as pituitary deficiency, autistic behaviours, epileptic seizures, etc. Optic Nerve Hypoplasia Stem Cell is the treatment for such ailments.
Few conventional treatment choices are available for patients detected with ONH-SOD; it typically concentrates on assisting the patients in coping with their incapacity. However, none of them is essentially treating the loss of optic nerve function. Optic nerve hypoplasia stem cell treatment in India has the aptitude to rejuvenate nerve cells in the optic nerve, permitting ONH-SOD patients to gain some vision.
People are searching for optic nerve hypoplasia stem cells in Delhi, India, but can’t seem to find the best optic nerve hypoplasia stem cell hospitals at affordable prices. Viezec helps those patients to find the best hospitals for the optic nerve hypoplasia stem cell in India
Causes of Optic Nerve Hypoplasia
Currently, various types of research are being processed where scientists are experimenting to find the exact cause of optic nerve hypoplasia. In most cases, it appears randomly.
According to the researcher’s analysis, optic nerve hypoplasia could result from vascular disruption.
Vascular disruption is temporarily disrupting an unborn baby’s blood flow, which can cause developmental delays and congenital disabilities.
Risk factors that have been associated with optic nerve hypoplasia include:
- First trimester bleeding
- Maternal smoking
- Young maternal age
- Maternal diabetes
- Preterm labour
- First pregnancy
- Low maternal weight gain or maternal weight loss
- Use of recreational drugs during pregnancy
- Use of some medications during pregnancy
Symptoms Associated with The Optic Nerve Hypoplasia
Optic nerve hypoplasia is present at birth. Although newborns don’t have excellent eyesight, symptoms may not appear until childhood. But in a few cases, infants have nystagmus and uncontrollable shaking of the eyes.
In most cases, the only symptom of ONH is vision loss. However, in some situations, like in which the optic nerve hypoplasia also accompanies neurodevelopmental abnormalities, your children may face developmental delays and behavioural difficulties.
Children with optic nerve hypoplasia may have issues with their pituitary glands. This can lead to a range of symptoms, including:
- Intellectual disability
- Delayed maturation
- Low blood sugar (hypoglycemia)
What Are the Tests to Diagnose Optic Nerve Hypoplasia
If your doctor suspects optic nerve hypoplasia, they will likely ask to perform an examination followed by several other tests.
During the examination, your healthcare provider will look for signs of ONH, such as:
- A pale or grey optic disc
- Thinning layers of the retina, the cells that line the back wall of the eye
- An eye shape that causes vision problems
- A smaller-than-normal optic disc is a structure where the optic nerve meets the rest of the eye
- A ring around the optic disc
Mentioned below are some other tests that your doctor will recommend you perform:
- MRI (Magnetic resonance imaging) – This test will create detailed images of soft tissue using a magnetic field and radio waves. With an MRI, the ophthalmologist can see the size of the optic nerve and view the optic chiasm. The optic chiasm is the place within the brain where some of the nerves from each eye cross. An MRI can also show any other brain abnormalities that may be present.
- Optical coherence tomography (OCT) – This examination is a non-invasive method of recording images of the back of the eye.
- If hormonal or pituitary problems are suspected, along with optic nerve hypoplasia, your doctor may run blood tests to check hormone levels.
Stem Cell Treatment for Optic Nerve Hypoplasia
Umbilical cord collection and preliminary testing.
It is a common practice in India for mothers to voluntarily donate the umbilical cord blood from the birth of their kids. Every mom who enters a hospital in India to give birth is spontaneously tested for all main sicknesses. Comprehensive family histories are also taken from each mother before donation. Only females who have been fully screened and found to be totally healthy are allowed to donate their umbilical cord and umbilical cord blood.
Second Round of Testing
The second step in the screening procedure happens in the laboratory once the collected samples have been verified affirmatively for communicable ailments; it is then transported to our laboratories and officially become the property. From this phase, it is mandatory for each and every sample to be processed and provided to the patient. The gathered samples are then run through the second round of testing and, while following the donor’s prerequisite, also carries out testing for cytomegalovirus, micro-organisms (aerobic bacteria, anaerobic bacteria, fungi, etc.), survival rate, stem cell surface indicators and stem cell biological characteristics (colony forming aptitude, differential capability) in each step to safeguard the highest quality to its cell products.
The stem cells derived from each umbilical cord are sowed into a flask filled with a culture medium. This medium does not have any animal products (such as fetal calf serum), but it is heightened with cell growth factors. The flasks are positioned in a sterilized, temperature and humidity-controlled incubator. The stem cell treatment for optic nerve hypoplasia is considered best suited. The stem cells are lengthened in the culture medium. Once the culturing is done, the culture mediums are splashed away and harvested.
The cell products are then cryo-preserved and stored at a consistent -196 degree Celsius temperature with an automatic supply of liquid nitrogen using the exceedingly advanced Thermogenesis Bio Archive system. This technology permits for integrated control rate of freezing that absolutely avoids unexpected drops in temperature. Our cryo-preservation storage equipment is also fortified with 24h real-time control system, and in any situation of power failure or another emergency, a redundant fail-safe power supply guarantees that normal operation is implemented. Our vacuum protection system can uphold appropriate temperatures for up to 20 days without supplementing of liquid nitrogen. The Optic nerve hypoplasia Hospital ensures efficient storage of the stem cells for further use.
Packing and Transport
All consignments of stem cells undergo final testing. During this procedure, they are tested for both quantities as well as quality. Once the stem cells are reckoned safe, each unit is positioned into either a sterile vial or a sterile IV bag for future transplantation. All merchandise is separately catalogued and traced while in transit. Our cell transplants come to pass two to three days a week. All of our cells are processed as per the requirement. Our cell products are verified, treated and kept fresh, giving us the highest stem cell sustainability count and the maximum effectiveness. We provide the best optic nerve hypoplasia stem cell treatment in Delhi with our network of experienced hospitals.
Stem Cell Implantation for Optic Nerve Hypoplasia
Implantation Of Stem Cells: Stem cell implantation can be done in the following ways.
- Intravenous administration
- Intrathecal (lumber puncture)
- Liberation angioplasty
- Surgical administration for stroke
The purpose of our stem cell treatment is to reinstate neurological function in the brain/spinal cord lesion region, thus, plethora of improvements are suitable and can be opted after the treatment, the previous patients have shown signs of following:
- Improved visual insight
- Improved light perception
- Enlarged visual field
- Perkier night vision
- Abridged nystagmus
- Enriched strabismus
- Better-quality hormonal deficiencies
- Reduced autistic symptoms
It is vital and imperative to remember that as for any medical treatment, improvements cannot be promised. Please contact us for more info, regarding the possible improvements for any specific case. If you are looking for assistance with Optic nerve hypoplasia stem cell treatment in India, trust ViezecMedicalHealthCare, to provide you the best treatment.
Mechanism of Optic Nerve Hypoplasia
The stem cells that are used for the treatment of optic nerve hypoplasia are mesenchymal stem cells. Viezec Stem Cell Institute has successfully executed stem cell treatment on patients with expert care and precautions. These stem cells have been used to cure ONH and SOD (Septo-optic dysplasia).
The capacity of mesenchymal stem cells (MSCs) to differentiate into neural cells and to secrete neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factors (GDNF), which may promote the differentiation of grafted cells into neural cells, prevent apoptosis, enhance angiogenesis, suppress inflammatory infiltrates and sustain grafted cells.
These pathways not only help to maintain vision, but they also help to enhance significantly vision loss by the optic nerve and retinal ganglion cell regeneration.
Statistics Of Overall Improvement of Optic Nerve Hypoplasia Through Stem Cell Therapy
At Viezec Stem Cell Institute, we believe there are always possibilities and hope patients deserve access to safe and effective stem cell therapy for erectile dysfunction. We aim to provide you with the best hospitality experiences by attending to our patients and their families in many ways. Our staff consists of specialists who are familiar with treating patients. With a team of experts and assistants, we can provide top-quality services to all guests under one roof for their convenience.
Optic Nerve Hypoplasia FAQ’s
- What are optic nerve and optic nerve hypoplasia?
The optic nerve is a collection of more than a million nerve fibres that transmit visual signals from the eye to the brain. The optic nerve develops during the first trimester of pregnancy.
Optic nerve hypoplasia (ONH) is a condition present at birth in which the optic nerve is underdeveloped.
- What visual problems are associated with optic nerve hypoplasia?
Most people with ONH have abnormal eye movements (nystagmus), and vision can range from no light perception to good functional or even full vision in one eye. In addition, children with ONH may have brain malformations and pituitary problems.
- Does ONH get worse over time?
In general, ONH is a stable and non-progressive condition which does not deteriorate. Vision may improve slightly, and nystagmus may decrease over time.
- What are the common causes of optic nerve hypoplasia?
In most cases, the cause of ONH is never found. However, sometimes the underdeveloped optic nerve can be associated with maternal factors during pregnancy, such as young maternal age; diabetes; use of alcohol, drug or some epilepsy drugs.
Treatment Results Of Optic Nerve Hypoplasia at Viezec
Through stem cell therapy by Viezec, improvements can be seen in the symptoms of the patients. The main motive of stem cell therapy for ONH is to renew the neurological function in the brain/spinal cord, which was earlier disrupted. After stem cell treatment, significant improvements can be seen in the patients. Most patients with optic nerve disorders suffer from optical acuity, visual field, light sensitivity, night vision, strabismus, and nystagmus; therapies using mesenchymal stem cells demonstrated good progress. In comparison, treatment with stem cells has led to a substantial slowdown in vision deterioration in patients with advanced conditions.
Optic Nerve Hypoplasia Patient Stories
I was looking for a stem cell treatment for my baby, and I found this. It’s effective and affordable, and the results are outstanding. After my treatment, I was able to experience better vision capabilities,
Hi, I am George Buyers, father of Sadie Buyers. My daughter has optic nerve hypoplasia, and for the past several years, we have been looking for an effective and safe treatment method for my kid. But every time, we only get rejection
Belli lost her sight in a matter of weeks in 2014 because of a severe case of optic neuritis – inflammation of an optic nerve that causes gradually blurry vision as the nerve could no longer interconnect with the brain
Katie is a 4 year old kid and she traveled to India with her parents so as to get stem cell treatment for optic nerve hypoplasia. Katie was first treated with stem cells in April of 2018 via Viezec.
The Staff at Viezec Care will call you following one month, two months and a half year to see the improvement of the treatment. This encourages us refine our conventions to improve further. You can likewise require some other assistance on the off chance that required.
Certificate of Analysis for Optic Nerve Hypoplasia Patient
Before the transplantation procedure, a few portions of blood, bone marrow, and other microorganisms that need treatment are sent to a certified research facility to separate and improve the cells.
At Viezec Stem Cell Institute, every patient gets a certified authentication number of cells for the process.
Optic Nerve Hypoplasia Patient Video’s
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