Retinal detachment defines an emergency condition in which a thin layer of skin (retina) at the back of the eye is detached from its usual location.
Retinal detachment distinguishes the retinal cells from the blood vessels that contain oxygen and food. The longer the retinal detachment stays unresolved, the greater your chance of permanent visual damage in the affected eye.
Will you know something about the Retinal Detachment?
Anybody may have a retinal detachment, but some individuals are at greater risk. You are at higher risk if you:
- You or a family member had a retinal separation before you had a severe eye injury
- You have had eye operations, such as cataract surgery.
Any other eye conditions can also place you at higher risk, including:
- Retinopathy with diabetes (a condition in people with diabetes that affects blood vessels in the retina)
- Extreme short-sightedness (myopia), particularly a serious form called degenerative myopia.
- Posterior vitreous detachment; (when the gel-like fluid in the centre of the eye pulls away from the retina)
- Many other eye conditions, including retinoschisis (when the retina is split into 2 layers) or lattice degeneration (thinning of the retina)
Speak to the eye specialist if you are worried about your chance of retinal detachment.
There are many causes of retinal detachment, but ageing or eye injuries are the most common causes.
There are three forms of retinal detachment: rhegmatogenous, tractional, and exudative. Each type occurs because of another problem that causes your retina to shift away from the back of your eye.
If only a small portion of the retina is detached, you do not have any effects.
Although if more of your retina is removed, you will not be able to see as well as usual, and you may experience other sudden effects, including: • a lot of new floaters (small black spots or squiggly lines flying through your vision) • light bursts in one eye or both eyes.
- Dark shadow or “curtain” on the edges or in the middle of your field of vision;
The retina detachment is a medical emergency. If you have signs of a retinal detachment, it is necessary to go to the eye doctor or emergency room immediately.
Symptoms of retinal detachment frequently develop rapidly. If the retinal detachment is not treated promptly, more of the retina will detach—which raises the risk of permanent vision loss or blindness.
Diagnosis of Retinal Detachment
Retinal detachment can be classified into three distinct categories:
There is retinal vein leakage. It is the most common of these. A retinal tear triggers it. On the whole, ageing is a big cause of it. This is because when the vitreous gel that covers your eyeball steadily pulls away from the retina, you lose your eyesight. The disease is termed near-sightedness, which is the result of either eye surgery or an injury to the eye, as well as refractive error.
Acceleration-sensitive – This kind of retinal detachment occurs if the retina has been weakened by diabetes, usually when the blood vessels in the back of your eye have been compromised.
In order to cause exudation. If there is a build-up of fluid behind the retina, this type exists. Your retina is pulled away from the tissue behind it by the blood. Many common disorders are caused by leaky blood vessels, such as inflammation, and age-related macular degeneration.
A practitioner can dilate the pupil by using eye drops. To check the retina’s state, they can use a special instrument called a retinal ophthalmoscope. As well as snapping a snapshot of your retina, they will even like to capture your retinas’ blood vessels.
Get Stem Cell Therapy for Retinal Detachment
The RPE is a pigmented layer of cells that distinguishes the photoreceptors, which are light-sensitive cells, from the nourishing blood vessels, or retinal capillaries, at the back of the eye. The RPE is essential for preserving normal retinal photoreceptor health, and it helps the photoreceptors. In the development of age-related macular degeneration and sub-types of retinitis pigmentosa, the RPE plays a central role. Progressive deterioration of vision, culminating in blindness, frequently follows these disorders.
How Stem Cell Therapy for Retinal Detachment works?
Stem cells are embryonic cells that can multiply and become more adult. In layman’s words, they are extremely proliferative, which means that there is no upper limit to the amount of mature cells a stem cell source can produce. A strong case can be made on this basis that stem cell transplant therapy is an alternative cure for different pathologies. Progressive depletion of photoreceptor cells and outer nuclear layers cause degenerative retinal disorders, which eventually originates in gradually dim vision. Stem cell treatment has the potential capacity to replace the compromised cells in the diseased retina, using new cells originating from the stem cells. They may also do several roles, such as controlling the immune system, protecting neurons against apoptosis, and releasing neurotrophins. Since there has been recent improvement in the use of stem cells in laboratory procedures, phase I/II clinical trials have been given the green light. Studies on stem cell transplantation to combat degenerative eye disorders such as retinitis pigmentosa, Stargardts’ macular dystrophy, and age-related macular degeneration have shown this treatment to be an exciting method to help recover vision. The primary aim of this study is to showcase novel techniques of stem cell treatment for degenerative retinal diseases.
.What to Expect from Stem Cell Treatment for Retinal Detachment?
Because of this, people conclude that retinal detachment surgery is rarely painful. Pressure relievers, such as paracetamol or ibuprofen, can help ease any discomfort you feel in the eye following surgery.
If you’ve had eye surgery, the white of the eye will appear red and your eyelid may appear swollen. During the first month after surgery, you can find a faint watery eye and a gritty feeling. When redness, eyelid swelling, and watering intensify, it will begin to get better.
A individual with an eye operated on can initially have vision that is blurred. It may take several weeks or months for the final outcome to be completely developed, and you may need new lenses. Your surgeon will speak to you about your vision’s final result.
VIP Treatment to Patients at Viezec
- The therapy sessions given to the patients at Viezec occur in the VIP treatment room in the advanced clinic.
- 24*7 supervision is maintained on the patients by the efficient medical team.
- Viezec highly recommends the patients stay for a minimum of 3 days in Hospital.
The following is the structure that is followed during the implantation stage:
- Intravenous administration
- Liberation angioplasty
- Intrathecal (lumber puncture)
- Surgical administration for stroke
- What is the prevalence of retinal detachment?
This is an unusual phenomenon. Retinal detachment affects only 6-8 individuals out of 10,000. Retinal detachment may happen at any age, but it is more frequent in people in their forties and fifties. Men are more affected than women, and Caucasians are more affected than Blacks.
- What kinds of accidents can cause retinal detachment?
Retinal fractures, holes, or tears caused by direct damage to the eye may occur days, weeks, months, or even years after the injury.
- Is it possible for retinal detachment to result in complete blindness?
Yes, even a mild vision blockage caused by partial retinal detachment will lead to blindness if not treated promptly.
It may take several months to see a change in vision, and in several situations, it will never completely recover. Patients with persistent retinal detachment will also restore no vision at all. For less vision returning, the more serious the detachment the longer it has been present. Because of this, it is important to see the ophthalmologist as soon as you first find any problems.
In certain cases, it is accepted that retinal disorders are permanent problems. The explanation for this is that it is actually unclear whether or not retinal cells regenerate spontaneously in a number of disorders that affect the retina, such as glaucoma, macular degeneration, and retinitis pigmentosa. Stem cell therapy is emerging as a potential solution for some eye conditions, such as retinitis pigmentosa, for which no treatment actually exists. Although the stem cell study has been continuing for some time, thanks to creative and cutting-edge technology and new fields related to stem cells, stem cell therapy is proving successful in treating all of the diseases which previously could not be treated.
If provoked, there is no way to revert retinal cell degeneration. The treatment’s primary aim is to delay or discourage the condition from worsening. It is focused on using everything we have left to recover your remaining vision. Researchers also performed a thorough analysis to determine the best possible means of treating retinal disease using stem cell therapy. A wide number of scholars have attempted to comprehensively outline the whole process, while others have limited their attention to a particular disease or a few diseases.
The stem cell/retinal cell integration platform is focused on doing a perfect job of restoring the retinal cells that have been destroyed as a result of retinal degeneration. To replicate the retinal cells as similarly as possible, these cells should be more analogous to the retinal cells. As this form of cell therapy has been attempted before in the treatment of macular degeneration, in which the peripheral retina’s autologous Retinalpigmentepithelium (RPE) cells are transplanted into the submacular space, it still has the ability to yield positive results. However, the insufficient availability of these cells and genetic deficiencies have limited the effectiveness of cell replacement therapy in such patients. The retinal cells that are derived from the stem cells are an infinite supply of stem cells for cell replacement therapy.
Alternatively, the stem cells could be grown in an incubator in vitro. The cells are inserted into the subretinal space once they have evolved to a reasonable amount, and their functional potential is then tracked. Nevertheless, the daunting challenge of maintaining the cultured cells alive in the artificial atmosphere necessitates continuing maintenance of the setting. Additionally, we will use pluripotent cells found in the skin or other tissues, resulting in a more complex approach. In order to grow the retinal pigment epithelium cells, these stem cells were returned to the embryonic stage and differentiated. Any process of developing and injecting cells into the subretinal space carries with it inherent difficulties. When performing the procedure, most of the cells die, with some cells failing to adhere to the retina and still remaining in the subretinal space. For several of these questions, modern therapies focus on tissue engineering. This RPE cell-retinal cell integration technology assists in achieving the necessary RPE cell integration with the retina.
The retinal condition was treated using the designed microsurgical instrument and the RPE patch engineered to contain a monolayer of human embryonic stem cells. There was an increase in visual acuity in all the patients that received this treatment. The regeneration and longevity of retinal pigment epithelium cells contributed to the change in vision. Immunosuppressive medications were the only form of medication offered. One thing is for sure: With stem cell therapies, patients today have several more treatment opportunities for multiple eye disorders.
Retinitis pigmentosa is a hereditary condition that starts with gradual weakening of the retina and progresses to complete blindness. Currently, no effective treatment options exist for the condition. A substantial number of these studies use primates. This disease is currently in the early stages of progress for stem cell treatment. Stargardt’s maculardystrophy is a disorder in which patients undergo stem cell treatment in order to create a proof-of-concept.
Another technique for retinal cell regeneration is to use Muller glial cells. There is a retinal healing process, like the one in Zebrafish, in cold-blooded vertebrates. The Muller glial cells function as a reservoir of retinal stem cells to assist with retinal damage repair. The Muller glial cells, while present in animals, are unable to differentiate into retinal cells because they are unable to join the cell cycle. Researchers are undertaking human clinical trials to determine whether stem cells derived from these cells could be used for treatment of the eye.
These previous experiments that used the Muller glial cells used neurotoxins to destroy the retinal cells in order to promote Muller glial cell differentiation. But owing to the neurotoxicity, the retinal ganglionic cells were destroyed. A subsequent study noted that the viral vectors used in the past were incorrect and that the genes should be transmitted to Muller glial cells to activate them. The trial was successful, and as a result, rod photo receptor cells were created.
While the stem cell therapies are in their early stages, great strides have been made in their development, and a number of potential treatments for retinal diseases are in the process of being discovered.
Viezec Treatment Procedure
- Pick up from the Airport to the Hospital
- Interaction between Dr and Patient, to clear all their doubts at that time
- Admission procedure
- Clinical examination & Lab test will be done prescribed by the doctor
- Supportive Therapy
- Stem cell Procedure
- Supportive therapies
- Supportive Therapy
- Discharging formalities
- Drop back to the Airport
- For Admission, carry the identity card (Passport/ Pan Card / Driving License)
- Carry the hard copy of Patient reports