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Critical Limb Ischemia
Critical Limb Ischemia (CLI) is a severe obstruction of the arteries, distinctly decreasing blood flow to the hands, feet and legs and progressing to the point of severe pain, skin ulcers, gangrene or sores. It necessitates instantaneous treatment to re-establish blood flow to the affected region or regions. The risk factors for critical limb ischemia consist of:

  • Desk bound lifestyle
  • Overweight or obesity
  • High blood pressure
  • Diabetes
  • Smoking
  • Age (Males over 60 and females after menopause)
  • High cholesterol
  • Family history of vascular disease

Symptoms


Following symptoms specify that you have critical limb ischemia.

  • Gangrene
  • Solidifying of the toenails
  • Absent or reduced pulse in the legs or feet
  • Toe or foot sores, infections or ulcers that will not heal or reconcile very sluggishly
  • Noticeable reduction in the temperature of your lower leg or foot compared to the rest of your body
  • Severe pain or numbness in the legs and feet while not moving identified as rest pain
  • Shiny, smooth, parched skin in the legs or feet

Pain at rest, gangrene and non-healing wounds are the indicator of Critical Limb Ischemia. It is described as a sweltering pain in the arch or distal foot that befalls while the patient is reclining but is relieved when the patient returns to a position in which the feet are dependent. Objective hemodynamic parameters that carry the analysis of critical limb ischemia consist of an ankle-brachial index of 0.4 or less, an ankle systolic pressure of 50 mm Hg or less, or a toe systolic pressure of 30 mm Hg or less. Interference might consist of conservative therapy, revascularization or amputation. Progressive gangrene, speedily enlarging wounds or unremitting ischemic rest pain can specify a danger to the limb and recommend the need for revascularization in patients without excessive operative risks. Bypass grafts are generally necessary owing to the multilevel and distal nature of the arterial contraction in critical limb ischemia. Patients with diabetes are more likely than other patients to have distal disease that is less affable to bypass grafting. Equated with amputation, revascularization is more reasonable and is linked with better pre-operative indisposition and mortality. Limb preservation should be the objective in most patients with critical limb ischemia.

Treatment


We use the matchless technology of Mesenchymal stem cells mined from Wharton’s jelly (WJ) for treating Lower Limb Ischemia.  WJ-MSCs offer economical and pain-free collection technique that might be cryogenic ally stockpiled and are tremendously advantageous for tissue engineering purpose. The treatment will come about in four steps which consist of:

Qualification for the treatment: Our specialists will probe your past medical history and symptoms to gauge the severity of your condition. A series of examinations will be implemented to comprehend the phase of disease. There will be pre-treatment evaluations and pre-operative evaluations. According to the test outcomes, our specialists will recommend the patient for further course of the process.

Source Extraction: With supervision and approval from the doctor, the source of extraction will be decided. On the whole, WJ-MSCs are the most potent allogenic sources obtainable. Stem cells from a healthy individual (the donor) are transported to the patient’s body. A bone marrow donor is considered for allogenic stem cell transplantation. A scraping from the interiors of the patient and his or her sibling’s cheek is tested to ascertain the tissue type. A professional will scrutinize to identity Human Leukocyte Antigens (HLAs). If the HLA on the donor cells are identical or alike, the transplant is more likely to be prosperous.

Laboratory Processing: The extracted samples will be sent to government approved cGMP lab for processing. The sample management will take place in an ultramodern facility in defiance with the ISO and GMP standards and using the newest technologies. The customer will receive a third party certificate from globally accredited lab for quality purpose.

Stem Cell Implantation: Once the stem cells are prepared to be implanted, the physician will pinpoint the most potent technique of infusion centered on the patient’s physical and mental well-being.

Lower Limb Ischemia Stem Cell Treatment Aftercare: in this stage, the patient will be asked to visit the doctor. The doctor might recommend some rehabilitation programmes such as communication and social interaction, physiological counseling and further assessment.

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